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ADAS-Cog中文版信效度分析
作者:李霞  肖泽萍  肖世富  朱敏捷  沈莉莉  王涛  钱时兴  陈超 
单位:上海交通大学医学院附属精神卫生中心  上海 200030 
关键词:阿尔茨海默病 阿尔茨海默病评估量表 信度 效度 
分类号:R749.16
出版年,卷(期):页码:2009,17(5):538-540
摘要:

目的:评价阿尔茨海默病评估量表认知部分(ADAS-Cog)的信度与效度。方法:采用ADAS-Cog评估135例阿尔茨海默病(AD)患者与78例健康对照老人。4周后对95名AD患者重测。评估ADAS-Cog量表的重测信度、平行效度和效标效度。结果:重测与初评结果除注意力项目不相关外,总分与其它11个项目分均显著相关(P<0.001)。ADAS-Cog总分与MMSE、ADL、NPI评分显著相关(P<0.01)。以DSM-Ⅳ为诊断AD的金标准,ADAS-Cog总分15.5分为区分AD与健康对照老人的最佳划界值,灵敏度与特异度分别为91.9%和89.5%,ROC曲线下面积(AUC)为0.95。结论:ADAS-Cog具有良好的信度与效度,适合在AD药物临床试验或纵向研究中使用。

Objective:To evaluate the validity and reliability of the Chinese version of Alzheimer's Disease Assessment Scale-Cognitive part (ADAS-Cog).Methods:135 subjects with Alzheimer'sdisease (AD) and 78 normal control subjects were assessed by ADAS-Cog. 95 subjects with AD were retested after 4 weeks. The test-retest reliability, parallel validity and criterion validity were examined.Results:Except the item of concentration, the other item scores of ADAS-Cog and its total score were significantly correlated to retest ones (P<0.001), ADAS-Cog total was correlated to the scores of MMSE, ADL and NPI (P<0.01). By the diagnostic criterion for AD from Diagnostic and Statistical Manual of Mental Disorders, the fourth version (DSM-IV), optimal cut-off points of ADAS-Cog was 15.5, with sensitivity 91.9% and specificity 89.5%, and the area under the curve (AUC) was 0.95.Conclusion:With satisfactory reliability and validity, ADAS-Cog can be applied to clinical researches or longitudinal studies on AD.

基金项目:
上海市科学技术委员会重大基础科研计划基金项目“老年轻度认知障碍的危险因素、早期表现和综合诊断标准研究”(07DJ14005);上海市卫生局青年科研计划项目“轻度认知损害的前瞻性研究”(054Y15)
作者简介:
参考文献:

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