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三等位基因5-HTTLPR与青少年重性抑郁障碍的关联研究
作者:马静1  苏林雁1  禹顺英2  梁珊3  丁军1  冯哲1  杨帆1  高维佳1  林佳妮1  黄春香1  刘铁桥1  谢光荣1 
单位:1. 中南大学湘雅二医院精神卫生研究所  湖南 长沙 410011 
2.
 上海交通大学医学院上海市精神卫生中心遗传学实验室  上海 200030 
3.
 长沙市未成年人心理发展咨询指导中心 
关键词:5-HTTLPR rs25531 青少年抑郁症 关联分析 
分类号:R395.1
出版年,卷(期):页码:2010,18(2):142-145
摘要:

目的:探讨三等位基因5-羟色胺转运体基因连锁多态区多态性(5-HTTLPR+rs25531)与青少年重性抑郁障碍之间有无关联。方法:404名研究对象(病例187人,正常对照217人)使用SNaPshot系统进行基因分型。结果:三等位基因5-HTTLPR与青少年抑郁症是否患病、抑郁严重程度、是否共病焦虑、是否出现自杀观念/行为/企图均无关。结论:尚不能认为三等位基因5-HTTLPR与青少年重性抑郁障碍有关。

Objective: To explore whether triallelic5 -HTTLPR polymorphism (5 -HTTLPR + rs25531) is related to adolescent major depressive disorder (MDD) in Chinese Han population or not. Methods: 404 Chinese Han subjects, including 187 adolescent patients with MDD and 217 normal control students were recruited to the research. 5-HTTLPR and rs25531 were genotyped using SNaPshot system. Results: Triallelic 5-HTTLPR polymorphism was not related with the occurrence, severity of adolescent MDD, and was not related to whether adolescent MDD comorbid anxiety or with suicidal behavior/attempt/ideation or not. Conclusion: Triallelic 5-HTTLPR polymorphism is not related to adolescent MDD.

基金项目:
国家自然科学基金资助项目(30770767)
作者简介:
参考文献:

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